研究员

吕守芹

中国力学学会/中国生物医学工程学会 生物力学专委会 委员 2011年至今;中国生物物理学会/生物力学及生物流变学专业委员会 委员 2006年至今;北京生物医学工程学会生物力学专业委员会 委员 2008年至今;中国生物物理学会单分子生物学分会 理事 2015年至今

简 历

1991.09-1995.07 山东省烟台师范学院物理系(鲁东大学) 理学学士

1995.09-1998.04 北京理工大学物理系 理学硕士

2001.09-2006.06 中国科学院力学研究所 理学博士

2013.12-2014.05 美国俄克拉荷马医学研究基金会 合作研究

2008.01-2015.12 中国科学院力学研究所 副研究员

2016.01-至今 中国科学院力学研究所 研究员


主要论著

1、Lü SQ, An HL, Zhang HL, and Long M. 2016. Structural basis for differences in dynamics induced by Leu versus Ile residues in the CD loop of Kir channels. Mol. Neurobiol., 53(9): 5948-5961.

2、Zhang X., Li L.D., Li N., Lü S.Q., Chen S.B., Mao D.B., and Long M. 2018. Salt bridge interactions within the β2 integrin α7 helix mediate force-induced binding and shear resistance ability. FEBS. J., 285:261-274.

3、Lü JM, Lü SQ, Zhang J, Liu ZP, Gao BX, Yao ZY, Wu YX, Potempa LA, Ji SR, Long M, and Wu Y. 2018. Conformational folding and disulfide bonding drive distinct stages of protein structure formation. Sci. Rep., 8:1494.

4、Hu JR, Chen SB, Hu WH, Lü SQ, and Long M. 2019. Mechanical point loading induces cortex stiffening and actin reorganization. Biophys. J., 117: 1405-1418.

5、Hu JR, Chen SB, Huang DD, Zhang Y, Lü SQ, and Long M. 2020. Global mapping of live cell mechanical features using PeakForce QNM AFM. Biophys. Rep., 6: 9-18.

6、Mao DB, Lü SQ, Zhang X, and Long M. 2020. Mechanically regulated outside-in activation of an I-domain-containing integrin. Biophys. J., 119: 966-977.

7、Lü SQ, Ding QH, Zhang MK, Long M. 2021. Multi-scale molecular dynamics simulations and applications on mechanosensitive proteins of integrins. Chin. Phys. B., 30(3), 038701.

8、Zhang MK, Chen SB, Hu JR, Ding QH, Li LD, Lü SQ, Long M. 2021. Mapping the morphological identifiers of distinct conformations via the protein translocation current in nanopores. Nanoscale. 13, 6053.

9、李林达,丁奇寒,陈深宝,吕守芹,龙勉,郭兴明。2021。CD44-配体相互作用的生物力学与功能调控。力学学报,53(2):539-553.

10、Wang TH, Lü SQ, Hao YJ, Su ZN, Long M, Cui YH. 2021. Influence of microflow on hepatic sinusoid blood flow and red blood cell deformation. Biophys. J., 120: 1-15.

11、Chen SB, Xue J, Hu JR, Ding QH, Zhou LV, Feng SL, Cui YH, Lü SQ, and Long M. 2020. Flow field analyses of a porous membrane-separated, double-layered microfluidic chip for cell co-culture. Acta Mech. Sin., 36(3): 754-767.

12、Li LD, Ding QH, Zhou J, Wu Y, Zhang MK, Guo XM, Long M, and Lü SQ. 2022. Distinct binding kinetics of E-, P- and L-selectins to CD44. FEBS J. 289: 2877-2894.

13、Zheng Z, Lü SQ, and Long M. 2022. Simulation and prediction of membrane fusion dynamics. Theor. App. Mech. Lett. 12: 100321.


获奖及荣誉
承担科研项目情况
研究方向

生物力学、生物物理