研究员

杜 宇

教育经历: 
(1) 2006-09 至 2010-07, 中国科学技术大学, 理论与应用力学系, 学士
(2) 2010-09 至 2016-07, 中国科学院大学, 一般力学与力学基础, 博士 
工作经历: 
(1) 2016-07 至 2017-08, 中国科学院力学研究所, 微重力实验室, 科研助理
(2) 2017-09 至 2022-08, 美国宾夕法尼亚大学,医学院,博士后 
(3) 2022-09 至 2023-12, 中国科学院力学研究所, 微重力实验室, 项目研究员 
(4) 2024-1至今, 中国科学院力学研究所, 微重力实验室, 研究员


简 历
主要论著
1. Du, Y., de Jong, I.E.M., Gupta, K., Waisbourd-Zinman, O., Har-Zahav, A., Soroka, C.J., Boyer, J.L., Llewellyn, J., Liu, C., Naji, A., et al. (2024). Human vascularized bile duct-on-a chip: a multi-cellular micro-physiological system for studying cholestatic liver disease. Biofabrication 16, 015004. 10.1088/1758-5090/ad0261. 
2. Li, W., Wu, Y., Hu, W., Zhou, J., Shu, X., Zhang, X., Zhang, Z., Wu, H., Du, Y., Lü, D., et al. (2023). Direct mechanical exposure initiates hepatocyte proliferation. JHEP Reports, 100905. https://doi.org/10.1016/j.jhepr.2023.100905.
3. de Jong, I.E.M., Hunt, M.L., Chen, D., Du, Y., Llewellyn, J., Gupta, K., Li, D., Erxleben, D., Rivas, F., Hall, A.R., et al. (2023). A fetal wound healing program after intrauterine bile duct injury may contribute to biliary atresia. Journal of hepatology. 10.1016/j.jhep.2023.08.010.
4. Du, Y., Polacheck, W.J., and Wells, R.G. (2022). Bile Duct-on-a-Chip. Methods in molecular biology (Clifton, N.J.) 2373, 57-68. 10.1007/978-1-0716-1693-2_4.
5. Li, W., Li, P., Li, N., Du, Y., Lü, S., Elad, D., and Long, M. (2021). Matrix stiffness and shear stresses modulate hepatocyte functions in a fibrotic liver sinusoidal model. American Journal of Physiology-Gastrointestinal and Liver Physiology 320, G272-G282. 10.1152/ajpgi.00379.2019.
6. Hsu, J.C., Du, Y., Sengupta, A., Dong, Y.C., Mossburg, K.J., Bouché, M., Maidment, A.D.A., Weljie, A.M., and Cormode, D.P. (2021). Effect of Nanoparticle Synthetic Conditions on Ligand Coating Integrity and Subsequent Nano-Biointeractions. ACS Appl Mater Interfaces 13, 58401-58410. 10.1021/acsami.1c18941.
7. Khandekar, G., Llewellyn, J., Kriegermeier, A., Waisbourd-Zinman, O., Johnson, N., Du, Y., Giwa, R., Liu, X., Kisseleva, T., Russo, P.A., et al. (2020). Coordinated development of the mouse extrahepatic bile duct: Implications for neonatal susceptibility to biliary injury. Journal of hepatology 72, 135-145. 10.1016/j.jhep.2019.08.036.
8. Fried, S., Gilboa, D., Har-Zahav, A., Lavrut, P.M., Du, Y., Karjoo, S., Russo, P., Shamir, R., Wells, R.G., and Waisbourd-Zinman, O. (2020). Extrahepatic cholangiocyte obstruction is mediated by decreased glutathione, Wnt and Notch signaling pathways in a toxic model of biliary atresia. Scientific reports 10, 7599. 10.1038/s41598-020-64503-5.
9. Du, Y., Khandekar, G., Llewellyn, J., Polacheck, W., Chen, C.S., and Wells, R.G. (2020). A Bile Duct-on-a-Chip With Organ-Level Functions. Hepatology (Baltimore, Md.) 71, 1350-1363.
10.1002/hep.30918. 10. Davidson, M.D., Song, K.H., Lee, M.H., Llewellyn, J., Du, Y., Baker, B.M., Wells, R.G., and Burdick, J.A. (2019). Engineered Fibrous Networks To Investigate the Influence of Fiber Mechanics on Myofibroblast Differentiation. ACS Biomater Sci Eng 5, 3899-3908. 10.1021/acsbiomaterials.8b01276.
11. Tong, C.F., Zhang, Y., Lü, S.Q., Li, N., Gong, Y.X., Yang, H., Feng, S.L., Du, Y., Huang, D.D., and Long, M. (2018). Binding of intercellular adhesion molecule 1 to β(2)-integrin regulates distinct cell adhesion processes on hepatic and cerebral endothelium. American journal of physiology. Cell physiology 315, C409-c421. 10.1152/ajpcell.00083.2017.
12. Du, Y., Li, N., and Long, M. (2018). Liver sinusoid on a chip. Methods Cell Biol 146, 105-134. 10.1016/bs.mcb.2018.06.002.
13. Yang, H., Li, N., Du, Y., Tong, C., Lü, S., Hu, J., Zhang, Y., and Long, M. (2017). Neutrophil adhesion and crawling dynamics on liver sinusoidal endothelial cells under shear flow. Experimental cell research 351, 91-99. 10.1016/j.yexcr.2017.01.002.
14. Du, Y., Li, N., Yang, H., Luo, C., Gong, Y., Tong, C., Gao, Y., Lü, S., and Long, M. (2017). Mimicking liver sinusoidal structures and functions using a 3D-configured microfluidic chip. Lab on a chip 17, 782-794. 10.1039/c6lc01374k.
15. Du, Y., Peng, S., Cui, Y., Lü, S., Zhang, Y., and Long, M. (2015). Combined modeling of cell aggregation and adhesion mediated by receptor–ligand interactions under shear flow. Theoretical and Applied Mechanics Letters 5, 216-221. https://doi.org/10.1016/j.taml.2015.09.004.
16. Li, Z., Gong, Y., Sun, S., Du, Y., Lü, D., Liu, X., and Long, M. (2013). Differential regulation of stiffness, topography, and dimension of substrates in rat mesenchymal stem cells. Biomaterials 34, 7616-7625. 10.1016/j.biomaterials.2013.06.059.


获奖及荣誉
承担科研项目情况
研究方向
1.生物力学 
2.肝脏疾病
3.(类)器官芯片